Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents

The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critica...

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Main Authors:	Dávid Illés Nagy, Alajos Grün, Sándor Garadnay, István Greiner, György Keglevich
Format:	Article
Language:	English
Published:	MDPI AG 2016-08-01
Series:	Molecules
Subjects:	hydroxymethylenebisphosphonic acid (dronic acid) derivatives solvent P-reagents synthesis
Online Access:	http://www.mdpi.com/1420-3049/21/8/1046

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spelling	doaj-dff5b48dcfce47cfb187e57e0ec335952020-11-24T22:39:59ZengMDPI AGMolecules1420-30492016-08-01218104610.3390/molecules21081046molecules21081046Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different SolventsDávid Illés Nagy0Alajos Grün1Sándor Garadnay2István Greiner3György Keglevich4Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryGedeon Richter Plc., 1475 Budapest, HungaryGedeon Richter Plc., 1475 Budapest, HungaryDepartment of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, HungaryThe syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.http://www.mdpi.com/1420-3049/21/8/1046hydroxymethylenebisphosphonic acid (dronic acid) derivativessolventP-reagentssynthesis
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Dávid Illés Nagy Alajos Grün Sándor Garadnay István Greiner György Keglevich
spellingShingle	Dávid Illés Nagy Alajos Grün Sándor Garadnay István Greiner György Keglevich Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents Molecules hydroxymethylenebisphosphonic acid (dronic acid) derivatives solvent P-reagents synthesis
author_facet	Dávid Illés Nagy Alajos Grün Sándor Garadnay István Greiner György Keglevich
author_sort	Dávid Illés Nagy
title	Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_short	Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_full	Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_fullStr	Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_full_unstemmed	Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents
title_sort	synthesis of hydroxymethylenebisphosphonic acid derivatives in different solvents
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2016-08-01
description	The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.
topic	hydroxymethylenebisphosphonic acid (dronic acid) derivatives solvent P-reagents synthesis
url	http://www.mdpi.com/1420-3049/21/8/1046
work_keys_str_mv	AT davidillesnagy synthesisofhydroxymethylenebisphosphonicacidderivativesindifferentsolvents AT alajosgrun synthesisofhydroxymethylenebisphosphonicacidderivativesindifferentsolvents AT sandorgaradnay synthesisofhydroxymethylenebisphosphonicacidderivativesindifferentsolvents AT istvangreiner synthesisofhydroxymethylenebisphosphonicacidderivativesindifferentsolvents AT gyorgykeglevich synthesisofhydroxymethylenebisphosphonicacidderivativesindifferentsolvents
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Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents

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