Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents

• Main Authors: Dávid Illés Nagy, Alajos Grün, Sándor Garadnay, István Greiner, György Keglevich
• Format: Article
• Language: English
• Published: MDPI AG 2016-08-01
• Series: Molecules
• Subjects: hydroxymethylenebisphosphonic acid (dronic acid) derivatives; solvent; P-reagents; synthesis
• Online Access: http://www.mdpi.com/1420-3049/21/8/1046
• ISSN: 1420-3049

The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.