Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts have an abnormal pattern of PLC and PLD activ...

Full description

Bibliographic Details
Main Authors: Bassam Haidar, Stephanie Mott, Betsie Boucher, Ching Yin Lee, Michel Marcil, Jacques Genest, Jr.
Format: Article
Language:English
Published: Elsevier 2001-02-01
Series:Journal of Lipid Research
Subjects:
protein kinase C
phospholipase C
phospholipase D
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520316862

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520316862

Similar Items