The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation.

The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation.

Studies have shown that a major metabolite of the red ginseng ginsenoside Rb1, called 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (GPD), exhibits anticancer properties. However, the chemotherapeutic effects and molecular mechanisms behind GPD action in human melanoma have not been previously inves...

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Bibliographic Details
Main Authors: Soouk Kang, Jong-Eun Kim, Nu Ry Song, Sung Keun Jung, Mee Hyun Lee, Jun Seong Park, Myeong-Hun Yeom, Ann M Bode, Zigang Dong, Ki Won Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4138097?pdf=render

Internet

http://europepmc.org/articles/PMC4138097?pdf=render

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