Hydrogen Peroxide Affects Growth of S. aureus Through Downregulation of Genes Involved in Pyrimidine Biosynthesis

Hydrogen Peroxide Affects Growth of S. aureus Through Downregulation of Genes Involved in Pyrimidine Biosynthesis

Reactive oxygen species (ROS) play a crucial role in the cellular defense against S. aureus, as evidenced by the importance of this pathogen in patients lacking the ROS-generating phagocyte NADPH oxidase NOX2. ROS concentrations required to kill S. aureus in vitro are much higher than those found in...

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Bibliographic Details
Main Authors: Hélène Buvelot, Myriam Roth, Vincent Jaquet, Andrey Lozkhin, Adriana Renzoni, Eve-Julie Bonetti, Nadia Gaia, Floriane Laumay, Michéle Mollin, Marie-José. Stasia, Jacques Schrenzel, Patrice François, Karl-Heinz Krause
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
S. aureus
hydrogen peroxide
pyrimidine metabolism
neutrophils
carA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.673985/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.673985/full

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