N-terminal prolactin-derived fragments, vasoinhibins, are proapoptoptic and antiproliferative in the anterior pituitary.

The anterior pituitary is under a constant cell turnover modulated by gonadal steroids. In the rat, an increase in the rate of apoptosis occurs at proestrus whereas a peak of proliferation takes place at estrus. At proestrus, concomitant with the maximum rate of apoptosis, a peak in circulating leve...

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Bibliographic Details
Main Authors: Jimena Ferraris, Daniela Betiana Radl, Sandra Zárate, Gabriela Jaita, Guadalupe Eijo, Verónica Zaldivar, Carmen Clapp, Adriana Seilicovich, Daniel Pisera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21760910/?tool=EBI