Synthesis of orotic acid derivatives and their effects on stem cell proliferation

Orotic acid esters and several N-arylhydrazones derivatives were synthesized and evaluated for their stem cell proliferation potential with human stromal stem cells (hMSCs) which was never studied before. Some of the derivatives exhibit convincing upregulation of proliferation which is believed to b...

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Bibliographic Details
Main Authors: Syed Saeed Ali, Mahmood Amer, Alfayez Musaad, Hosten Eric C., Betz Richard, Al-Obaid Abdulrahman M., Ghadeer Abdulrahman, Bari Ahmed
Format: Article
Language:English
Published: De Gruyter 2020-06-01
Series:Open Chemistry
Subjects:
Online Access:http://www.degruyter.com/view/j/chem.2020.18.issue-1/chem-2020-0096/chem-2020-0096.xml?format=INT