Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells

Canine and human osteosarcomas (OSA) share similarities. Novel therapies are necessary for these tumours. The <i>Bacillus anthracis</i> toxin was reengineered to target and kill cells with high expressions of matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA). Sin...

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Bibliographic Details
Main Authors: Jonathan Mackowiak da Fonseca, Ivone Izabel Mackowiak da Fonseca, Marcia Kazumi Nagamine, Cristina de Oliveira Massoco, Adriana Tomoko Nishiya, Jerrold Michael Ward, Shihui Liu, Stephen Howard Leppla, Thomas Henrik Bugge, Maria Lucia Zaidan Dagli
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Toxins
Subjects:
toxin
canine osteosarcoma
<i>Bacillus anthracis</i>
anthrax
apoptosis
Online Access:https://www.mdpi.com/2072-6651/12/10/614

Internet

https://www.mdpi.com/2072-6651/12/10/614

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