The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

The decoration of the lipid A headgroups of the lipooligosaccharide (LOS) by the LOS phosphoethanolamine (PEA) transferase (LptA) in Neisseria spp. is central for resistance to polymyxin. The structure of the globular domain of LptA shows that the protein has five disulphide bonds, indicating that i...

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Bibliographic Details
Main Authors: Susannah Piek, Zhirui Wang, Jhuma Ganguly, Adam M Lakey, Stephanie N Bartley, Shakeel Mowlaboccus, Anandhi Anandan, Keith A Stubbs, Martin J Scanlon, Alice Vrielink, Parastoo Azadi, Russell W Carlson, Charlene M Kahler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4162559?pdf=render

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http://europepmc.org/articles/PMC4162559?pdf=render

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