Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats.

Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats.

We aimed to evaluate macrophages heterogeneity and structural, functional and inflammatory alterations in rat kidney by aldosterone + salt administration. The effects of treatment with spironolactone on above parameters were also analyzed. Male Wistar rats received aldosterone (1 mgkg-1d-1) + 1% NaC...

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Main Authors: Beatriz Martín-Fernández, Alfonso Rubio-Navarro, Isabel Cortegano, Sandra Ballesteros, Mario Alía, Pablo Cannata-Ortiz, Elena Olivares-Álvaro, Jesús Egido, Belén de Andrés, María Luisa Gaspar, Natalia de Las Heras, Vicente Lahera, Juan Antonio Moreno
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4701403?pdf=render

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http://europepmc.org/articles/PMC4701403?pdf=render

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