Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

Autocrine negative feedback regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT

Objectives: Long-chain fatty acids (LCFAs) released from adipocytes inhibit lipolysis through an unclear mechanism. We hypothesized that the LCFA receptor, FFAR4 (GPR120), which is highly expressed in adipocytes, may be involved in this feedback regulation. Methods and results: Liquid chromatography...

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Bibliographic Details
Main Authors: Anna Sofie Husted, Jeppe H. Ekberg, Emma Tripp, Tinne A.D. Nissen, Stijn Meijnikman, Shannon L. O'Brien, Trond Ulven, Yair Acherman, Sjoerd C. Bruin, Max Nieuwdorp, Zach Gerhart-Hines, Davide Calebiro, Lars O. Dragsted, Thue W. Schwartz
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
GPR120
FFAR4
Autocrine
Lipolysis
NEFA
GPCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301770

Internet

http://www.sciencedirect.com/science/article/pii/S2212877820301770

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