Clinical Relevance of Genomic Changes in Recurrent Pediatric Solid Tumors

PURPOSE: Relapsed/refractory pediatric cancers show poor prognosis; however, their genomic patterns remain unknown. To investigate the genetic mechanisms of tumor relapse and therapy resistance, we characterized genomic alterations in diagnostic and relapsed lesions in patients with relapsed/refract...

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Bibliographic Details
Main Authors: Boram Lee, Ji Won Lee, Joon Ho Shim, Je-Gun Joung, Jae Won Yun, Joon Seol Bae, Hyun-Tae Shin, Ki Woong Sung, Woong-Yang Park
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523318303140