Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes

Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes

Abstract Background The cytosolic arrestin proteins mediate desensitization of activated G protein-coupled receptors (GPCRs) via competition with G proteins for the active phosphorylated receptors. Arrestins in active, including receptor-bound, conformation are also transducers of signaling. Therefo...

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Bibliographic Details
Main Authors: Henrike Indrischek, Sonja J. Prohaska, Vsevolod V. Gurevich, Eugenia V. Gurevich, Peter F. Stadler
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Evolutionary Biology
Subjects:
Arrestin
Signaling
Gene duplication
Evolution
Receptor specificity
Retrogene
Online Access:http://link.springer.com/article/10.1186/s12862-017-1001-4

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http://link.springer.com/article/10.1186/s12862-017-1001-4

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