Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage.

Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage.

Osteopontin (OPN), a secreted protein involved in inflammatory processes and cancer, induces cell adhesion, migration, and activation of inflammatory pathways in various cell types. Cells bind OPN via integrins at a canonical RGD region in the full length form as well as to a contiguous cryptic site...

Full description

Bibliographic Details
Main Authors: Alexander Jürets, Marie Le Bras, Günther Staffler, Gesine Stein, Lukas Leitner, Angelika Neuhofer, Matteo Tardelli, Edvin Turkof, Maximilian Zeyda, Thomas M Stulnig
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4740464?pdf=render

Internet

http://europepmc.org/articles/PMC4740464?pdf=render

Similar Items