KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARα

KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARα

Abstract Background A hallmark of acute promyelocytic leukemia (APL) is the expression of PML/RARα fusion protein. Treatment with all-trans retinoic acid (ATRA) results in the terminal differentiation of neutrophil granulocytes. However, the underlying mechanisms remain largely unknown. Here, we ide...

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Bibliographic Details
Main Authors: Xinrui Wang, Huiyong Fan, Congling Xu, Guojuan Jiang, Haiwei Wang, Ji Zhang
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Cancer Cell International
Subjects:
KDM3B
APL
PML/RARα
H3K9me1/me2
Chromatin accessibility
Differentiation
Online Access:http://link.springer.com/article/10.1186/s12935-019-0979-7

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http://link.springer.com/article/10.1186/s12935-019-0979-7

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