Spinal Inhibition of GABAB Receptors by the Extracellular Matrix Protein Fibulin-2 in Neuropathic Rats

Spinal Inhibition of GABAB Receptors by the Extracellular Matrix Protein Fibulin-2 in Neuropathic Rats

In the central nervous system, the inhibitory GABAB receptor is the archetype of heterodimeric G protein-coupled receptors (GPCRs). Receptor interaction with partner proteins has emerged as a novel mechanism to alter GPCR signaling in pathophysiological conditions. We propose here that GABAB activit...

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Bibliographic Details
Main Authors: Marie-Amélie Papon, Yves Le Feuvre, Gabriel Barreda-Gómez, Alexandre Favereaux, Fanny Farrugia, Rabia Bouali-Benazzouz, Frédéric Nagy, Rafael Rodríguez-Puertas, Marc Landry
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
fibulin-2
disinhibition
GABAB receptor
neuropathic pain
spinal cord
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00214/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00214/full

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