Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions in the Pre-clinical Setting

Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions in the Pre-clinical Setting

Background:Ex situ donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic interventions. However, the wide variability in donor and graft characteristics between individual donor livers limits the comparabili...

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Bibliographic Details
Main Authors: Joseph A. Attard, Daniel-Clement Osei-Bordom, Yuri Boteon, Lorraine Wallace, Vincenzo Ronca, Gary Reynolds, M. T. P. R. Perera, Ye Htun Oo, Hynek Mergental, Darius F. Mirza, Simon C. Afford
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Surgery
Subjects:
normothermic
liver function
organ preservation
split liver technique
machine perfusion
Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2021.627332/full

Internet

https://www.frontiersin.org/articles/10.3389/fsurg.2021.627332/full

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