Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

Chagas disease or American trypanosomiasis is a worldwide public health problem. In this work, we evaluated 26 new propyl and isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives as potential trypanocidal agents. Additionally, molecular docking and enzymatic assays on trypanothione reducta...

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Bibliographic Details
Main Authors: Karla Fabiola Chacón-Vargas, Benjamin Nogueda-Torres, Luvia E. Sánchez-Torres, Erick Suarez-Contreras, Juan Carlos Villalobos-Rocha, Yuridia Torres-Martinez, Edgar E. Lara-Ramirez, Giulia Fiorani, R. Luise Krauth-Siegel, Maria Laura Bolognesi, Antonio Monge, Gildardo Rivera
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide
Trypanosoma cruzi
trypanothione reductase inhibitors
Online Access:http://www.mdpi.com/1420-3049/22/2/220

Internet

http://www.mdpi.com/1420-3049/22/2/220

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