Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation.

Lamins A and C, encoded by the LMNA gene, are filamentous proteins that form the core scaffold of the nuclear lamina. Dominant LMNA gene mutations cause multiple human diseases including cardiac and skeletal myopathies. The nuclear lamina is thought to regulate gene expression by its direct interact...

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Bibliographic Details
Main Authors:	Stephanie K Mewborn, Megan J Puckelwartz, Fida Abuisneineh, John P Fahrenbach, Yuan Zhang, Heather MacLeod, Lisa Dellefave, Peter Pytel, Sara Selig, Christine M Labno, Karen Reddy, Harinder Singh, Elizabeth McNally
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-12-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3001866?pdf=render

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http://europepmc.org/articles/PMC3001866?pdf=render

Altered chromosomal positioning, compaction, and gene expression with a lamin A/C gene mutation.

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