The structure-based cancer-related single amino acid variation prediction

Abstract Single amino acid variation (SAV) is an amino acid substitution of the protein sequence that can potentially influence the entire protein structure or function, as well as its binding affinity. Protein destabilization is related to diseases, including several cancers, although using traditi...

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Bibliographic Details
Main Authors: Jia-Jun Liu, Chin-Sheng Yu, Hsiao-Wei Wu, Yu-Jen Chang, Chih-Peng Lin, Chih-Hao Lu
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-92793-w