Specificity and Commonality of the Phosphoinositide-Binding Proteome Analyzed by Quantitative Mass Spectrometry

Specificity and Commonality of the Phosphoinositide-Binding Proteome Analyzed by Quantitative Mass Spectrometry

Phosphoinositides (PIPs) play key roles in signaling and disease. Using high-resolution quantitative mass spectrometry, we identified PIP-interacting proteins and profiled their binding specificities toward all seven PIP variants. This analysis revealed 405 PIP-binding proteins, which is greater tha...

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Bibliographic Details
Main Authors: Stephanie Jungmichel, Kathrine B. Sylvestersen, Chunaram Choudhary, Steve Nguyen, Matthias Mann, Michael L. Nielsen
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713007961

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http://www.sciencedirect.com/science/article/pii/S2211124713007961

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