IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis

IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis

Abstract Background Interleukin 9 (IL-9), produced mainly by T helper 9 (Th9) cells, has been recognized as an important regulator in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Astrocytes respond to IL-9 and reactive astrocytes always associate wit...

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Bibliographic Details
Main Authors: Xiaomei Liu, Feng Zhou, Weixiao Wang, Guofang Chen, Qingxiu Zhang, Ruixue Lv, Zijun Zhao, Xiangyang Li, Qian Yu, Jessica M. Meves, Hui Hua, Xiaocui Li, Xiaotian Wang, Hong Sun, Dianshuai Gao
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Journal of Neuroinflammation
Subjects:
IL-9
Astrocytes
LncRNA Gm13568
Notch1
Inflammatory cytokines
Experimental autoimmune encephalomyelitis (EAE)
Online Access:https://doi.org/10.1186/s12974-021-02156-5

Internet

https://doi.org/10.1186/s12974-021-02156-5

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