Adverse Prognostic Impact of the <i>KIT</i> D816V Transcriptional Activity in Advanced Systemic Mastocytosis

Adverse Prognostic Impact of the <i>KIT</i> D816V Transcriptional Activity in Advanced Systemic Mastocytosis

In systemic mastocytosis (SM), qualitative and serial quantitative assessment of the <i>KIT</i> D816V mutation is of diagnostic and prognostic relevance. We investigated peripheral blood and bone marrow samples of 161 patients (indolent SM (ISM), <i>n</i> = 40; advanced SM, A...

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Bibliographic Details
Main Authors: Nicole Naumann, Johannes Lübke, Sofie Baumann, Juliana Schwaab, Oliver Hoffmann, Sebastian Kreil, Vito Dangelo, Lukas Reiter, Peter Bugert, Thomas Kristensen, Karl Sotlar, Verena Haselmann, Sven Schneider, Georgia Metzgeroth, Christel Weiss, Henning D. Popp, Alice Fabarius, Wolf-Karsten Hofmann, Nicholas C. P. Cross, Andreas Reiter, Mohamad Jawhar
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
advanced SM
<i>KIT</i> D816V
allele burden
variant allele frequency
survival
Online Access:https://www.mdpi.com/1422-0067/22/5/2562

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https://www.mdpi.com/1422-0067/22/5/2562

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