Glycoengineering of interferon-β 1a improves its biophysical and pharmacokinetic properties.

Glycoengineering of interferon-β 1a improves its biophysical and pharmacokinetic properties.

The purpose of this study was to develop a biobetter version of recombinant human interferon-β 1a (rhIFN-β 1a) to improve its biophysical properties, such as aggregation, production and stability, and pharmacokinetic properties without jeopardizing its activity. To achieve this, we introduced additi...

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Bibliographic Details
Main Authors: Kyoung Song, In-Soo Yoon, Nam Ah Kim, Dong-Hwan Kim, Jongmin Lee, Hee Jung Lee, Saehyung Lee, Sunghyun Choi, Min-Koo Choi, Ha Hyung Kim, Seong Hoon Jeong, Woo Sung Son, Dae-Duk Kim, Young Kee Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4032242?pdf=render

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http://europepmc.org/articles/PMC4032242?pdf=render

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