TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2+ signaling in motor neurons

TARDBP pathogenic mutations increase cytoplasmic translocation of TDP-43 and cause reduction of endoplasmic reticulum Ca2+ signaling in motor neurons

The transactive response DNA binding protein (TDP-43) is a major component of the characteristic neuronal cytoplasmic inclusions seen in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Furthermore, pathogenic mutations in the gene encoding TDP-43, TARDBP, are found in sporadic...

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Bibliographic Details
Main Authors: R. Mutihac, J. Alegre-Abarrategui, D. Gordon, L. Farrimond, M. Yamasaki-Mann, K. Talbot, R. Wade-Martins
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Neurobiology of Disease
Subjects:
TDP-43
Ca2+ dysregulation
Bcl-2
Motor neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003817

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http://www.sciencedirect.com/science/article/pii/S0969996114003817

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