Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury

Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury

Background/Aims: Neurotoxic A1 astrocytes are induced by inflammation after spinal cord injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be related to A1-astrocyte activation. Mesenchymal stem cell (MSC) transplantation is a promising therapy for SCI, where transp...

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Bibliographic Details
Main Authors: Lin Wang, Shuang Pei, Linlin Han, Bin Guo, Yanfei Li, Ranran Duan, Yaobing Yao, Bohan Xue, Xuemei Chen, Yanjie Jia
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Mesenchymal stem cell
Exosomes
Spinal cord injury
Astrocytes
Inflammation
Online Access:https://www.karger.com/Article/FullText/494652

Internet

https://www.karger.com/Article/FullText/494652

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