Racemization of the Succinimide Intermediate Formed in Proteins and Peptides: A Computational Study of the Mechanism Catalyzed by Dihydrogen Phosphate Ion

Racemization of the Succinimide Intermediate Formed in Proteins and Peptides: A Computational Study of the Mechanism Catalyzed by Dihydrogen Phosphate Ion

In proteins and peptides, d-aspartic acid (d-Asp) and d-β-Asp residues can be spontaneously formed via racemization of the succinimide intermediate formed from l-Asp and l-asparagine (l-Asn) residues. These biologically uncommon amino acid residues are known to have relevance to aging and pathologie...

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Bibliographic Details
Main Authors: Ohgi Takahashi, Ryota Kirikoshi, Noriyoshi Manabe
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:International Journal of Molecular Sciences
Subjects:
succinimide
racemization
aspartic acid residue
nonenzymatic reaction
buffer catalysis
dihydrogen phosphate ion
enolization
proton transfer
computational chemistry
density functional theory
Online Access:http://www.mdpi.com/1422-0067/17/10/1698

Internet

http://www.mdpi.com/1422-0067/17/10/1698

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