Local genetic context shapes the function of a gene regulatory network

Gene expression levels are influenced by multiple coexisting molecular mechanisms. Some of these interactions such as those of transcription factors and promoters have been studied extensively. However, predicting phenotypes of gene regulatory networks (GRNs) remains a major challenge. Here, we use...

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Bibliographic Details
Main Authors: Anna Nagy-Staron, Kathrin Tomasek, Caroline Caruso Carter, Elisabeth Sonnleitner, Bor Kavčič, Tiago Paixão, Calin C Guet
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/65993