Tamoxifen suppresses paclitaxel-, vincristine-, and bortezomib-induced neuropathy via inhibition of the protein kinase C/extracellular signal-regulated kinase pathway

Chemotherapy-induced neuropathy is a highly problematic, dose-limiting effect of potentially curative regimens of cancer chemotherapy. When neuropathic pain is severe, patients often either switch to less-effective chemotherapy agents or choose to discontinue chemotherapy entirely. Conventional chem...

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Bibliographic Details
Main Authors: Masanobu Tsubaki, Tomoya Takeda, Mikihiro Matsumoto, Natsuki Kato, Shota Yasuhara, Yu-ichi Koumoto, Motohiro Imano, Takao Satou, Shozo Nishida
Format: Article
Language:English
Published: IOS Press 2018-10-01
Series:Tumor Biology
Online Access:https://doi.org/10.1177/1010428318808670