Opportunities and Challenges of Backbone, Sidechain, and RDC Experiments to Study Membrane Protein Dynamics in a Detergent-Free Lipid Environment Using Solution State NMR

Opportunities and Challenges of Backbone, Sidechain, and RDC Experiments to Study Membrane Protein Dynamics in a Detergent-Free Lipid Environment Using Solution State NMR

Whereas solution state NMR provided a wealth of information on the dynamics landscape of soluble proteins, only few studies have investigated membrane protein dynamics in a detergent-free lipid environment. Recent developments of smaller nanodiscs and other lipid-scaffolding polymers, such as styren...

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Bibliographic Details
Main Author: Stefan Bibow
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
RDC
NMR
Carr-Purcell-Meiboom-Gill (CPMG)
CEST
membrane protein dynamics
backbone
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00103/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00103/full

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