RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure

RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3′ Nuclease-resistant Mini-hairpin Structure

Selective gene silencing by RNA interference (RNAi) involves double-stranded small interfering RNA (ds siRNA) composed of single-stranded (ss) guide and passenger RNAs. siRNA is recognized and processed by Ago2 and C3PO, endonucleases of the RNA-induced silencing complex (RISC). RISC cleaves passeng...

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Bibliographic Details
Main Authors: Simon J Allison, Jo Milner
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Ago2
C3PO
nuclease-resistant DNA mini-hairpin
RNAi
SIRT1
therapy
3′-DNA/siRNA constructs
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116302803

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116302803

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