Ultrasound-assisted chiral derivatization of etodolac with (1R)-(−)-menthyl chloroformate for the determination of etodolac enanti

Ultrasound-assisted chiral derivatization of etodolac with (1R)-(−)-menthyl chloroformate for the determination of etodolac enanti

This study presents the first report of an ultrasound-assisted derivatization reaction between a carboxylic acid of etodolac (ETO) and a chiral derivatization reagent, (1R)-(−)-menthyl chloroformate (R-MCF). Fifty μL of deproteinated mouse serum containing ETO enantiomers was derivatized with 125 μL...

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Bibliographic Details
Main Authors: Yan Jin, Jing Zhao, Lydia Rhyman, Ponnadurai Ramasami, Yujin Shin, Kyung Min Jeong, Jeongmi Lee
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Arabian Journal of Chemistry
Subjects:
Enantiomeric separation
Etodolac
(1R)-(−)-menthyl chloroformate
Fluorescence detection
Response surface methodology
Diastereomer
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535215003135

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http://www.sciencedirect.com/science/article/pii/S1878535215003135

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