BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage

BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage

Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the e...

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Bibliographic Details
Main Authors: Li-xia Qin, Jie-qiong Tan, Hai-nan Zhang, Kousar Rizwana, Jia-hong Lu, Jian-guang Tang, Bo Jiang, Xiang-min Shen, Ji-feng Guo, Bei-sha Tang, Li-ming Tan, Chun-yu Wang
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2017/5094934

Internet

http://dx.doi.org/10.1155/2017/5094934

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