Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo

Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo

Higher cyclooxygenase 2 (COX-2) expression is often observed in aggressive colorectal cancers (CRCs). Here, we attempt to examine the association between COX-2 expression in therapy-refractory CRC, how it affects chemosensitivity, and whether, in primary tumors, it is predictive of clinical outcome...

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Bibliographic Details
Main Authors: Mahbuba Rahman, Krithika Selvarajan, Mohammad R. Hasan, Annie P. Chan, Chaoyang Jin, Jieun Kim, Simon K. Chan, Nhu D. Le, Young-Bae Kim, Isabella T. Tai
Format: Article
Language:English
Published: Elsevier 2012-07-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558612800960

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http://www.sciencedirect.com/science/article/pii/S1476558612800960

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