Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance

Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance

Multidrug resistance is a serious problem and a common cause of cancer treatment failure, leading to patient death. Although numerous reversal resistance inhibitors have been evaluated in preclinical or clinical trials, efficient and low-toxicity reversal agents have not been identified. In this stu...

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Bibliographic Details
Main Authors: Xingping Quan, Hongzhi Du, Jingjing Xu, Xiaoying Hou, Xiaofeng Gong, Yao Wu, Yuqi Zhou, Jingwei Jiang, Ligong Lu, Shengtao Yuan, Xiangyu Yang, Lei Shi, Li Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Chemistry
Subjects:
molecular docking
multidrug resistance (MDR)
P-glycoprotein (P-gp)
quinoline
reversal cancer resistance
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00820/full

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https://www.frontiersin.org/article/10.3389/fchem.2019.00820/full

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