Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight.

Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight.

Ceramides are known to promote insulin resistance in a number of metabolically important tissues including skeletal muscle, the predominant site of insulin-stimulated glucose disposal. Depending on cell type, these lipid intermediates have been shown to inhibit protein kinase B (PKB/Akt), a key medi...

Full description

Bibliographic Details
Main Authors: Rana Mahfouz, Rhéa Khoury, Agnieszka Blachnio-Zabielska, Sophie Turban, Nicolas Loiseau, Christopher Lipina, Clare Stretton, Olivier Bourron, Pascal Ferré, Fabienne Foufelle, Harinder S Hundal, Eric Hajduch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4109934?pdf=render

Internet

http://europepmc.org/articles/PMC4109934?pdf=render

Similar Items