No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis.

Apart from their role in the immune defence against pathogens evidence of a role of antimicrobial peptides (AMPs) in autoimmune diseases has accumulated in the past years. The aim of this project was to examine the functional impact of the human cathelicidin LL-37 and the mouse cathelicidin-related...

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Main Authors: D Kienhöfer, J Hahn, I Schubert, C Reinwald, N Ipseiz, S C Lang, È Bosch Borràs, K Amann, C Sjöwall, A E Barron, A J Hueber, B Agerberth, G Schett, M H Hoffmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0115474