Synthesis, crystal structure, DFT studies and biological activity of (Z)-3-(3-bromophenyl)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxyprop-2-en-1-one

Synthesis, crystal structure, DFT studies and biological activity of (Z)-3-(3-bromophenyl)-1-(1,5-dimethyl-1H-pyrazol-3-yl)-3-hydroxyprop-2-en-1-one

Abstract Background Nowadays, is emerging a new generation of highly promising inhibitors bearing the β-ketoenol functionality. The present work relates to the first synthesis, the structure determination, the DFT studies and the use of a new biomolecule designed with a β-ketoenol group bounded to a...

Full description

Bibliographic Details
Main Authors: Said Tighadouini, Redouane Benabbes, Monique Tillard, Driss Eddike, Khadija Haboubi, Khalid Karrouchi, Smaail Radi
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Chemistry Central Journal
Subjects:
β-Keto-enol-pyrazole
Single-crystal structure
NBO analysis
Reactivity indices
Fukui and Parr functions
Biological activity
Online Access:http://link.springer.com/article/10.1186/s13065-018-0492-4

Internet

http://link.springer.com/article/10.1186/s13065-018-0492-4

Similar Items