Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-<i>nor</i> Analogs of Vitamin D

Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-<i>nor</i> Analogs of Vitamin D

1,25-dihydroxyvitamin D<sub>3</sub> (1,25D3) is implicated in many cellular functions, including cell proliferation and differentiation, thus exerting potential antitumor effects. A major limitation for therapeutic use of 1,25D3 are potent calcemic activities. Therefore, synthetic analog...

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Bibliographic Details
Main Authors: Klaudia Berkowska, Aoife Corcoran, Małgorzata Grudzień, Agnieszka Jakuszak, Michał Chodyński, Andrzej Kutner, Ewa Marcinkowska
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
1,25-dihydroxyvitamin D<sub>3</sub>
vitamin D analogs
differentiation
CYP24A1
vitamin D receptor
affinity
TRPV6
megalin
Online Access:https://www.mdpi.com/1422-0067/20/17/4183

Internet

https://www.mdpi.com/1422-0067/20/17/4183

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