Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure.

Attenuated expression of apoptosis stimulating protein of p53-2 (ASPP2) in human acute leukemia is associated with therapy failure.

Inactivation of the p53 pathway is a universal event in human cancers and promotes tumorigenesis and resistance to chemotherapy. Inactivating p53 mutations are uncommon in non-complex karyotype leukemias, thus the p53-pathway must be inactivated by other mechanisms. The Apoptosis Stimulating Protein...

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Bibliographic Details
Main Authors: Marcus M Schittenhelm, Barbara Illing, Figen Ahmut, Katharina Henriette Rasp, Gunnar Blumenstock, Konstanze Döhner, Charles D Lopez, Kerstin M Kampa-Schittenhelm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3842400?pdf=render

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http://europepmc.org/articles/PMC3842400?pdf=render

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