Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.

Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.

Regulation of DNMT1 is critical for epigenetic control of many genes and for genome stability. Using phylogenetic analysis we characterized a block of 27 nucleotides in the 3'UTR of Dnmt1 mRNA identical between humans and Xenopus and investigated the role of the individual elements contained wi...

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Bibliographic Details
Main Authors: Charlotte E Rutledge, Ho-Tak Lau, Hazel Mangan, Linda L Hardy, Olaf Sunnotel, Fan Guo, Angus M MacNicol, Colum P Walsh, Diane J Lees-Murdock
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3930535?pdf=render

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http://europepmc.org/articles/PMC3930535?pdf=render

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