Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation

Abstract Activation of the T cell receptor (TCR) leads to the generation of a network of signaling events critical to the developmental decision making and activation of T cells. Various experimental approaches continue to identify new signaling molecules, adaptor proteins, and other regulators of T...

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Bibliographic Details
Main Authors: Elijah W. Chen, Joanna Brzostek, Nicholas R. J. Gascoigne, Vasily Rybakin
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-28106-5