PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice

PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice

Abstract Background Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27me3, which marks many transcriptionally silent genes throughout the mammalian genome. Although H3K27me3 is associated with silenced gene expression broadly, it remains unclear why some but not other PRC2 target genes req...

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Bibliographic Details
Main Authors: Emily Maclary, Michael Hinten, Clair Harris, Shriya Sethuraman, Srimonta Gayen, Sundeep Kalantry
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Genome Biology
Subjects:
X-inactivation
Polycomb
PRC2
EED
H3K27me3
Imprinting
Online Access:http://link.springer.com/article/10.1186/s13059-017-1211-5

Internet

http://link.springer.com/article/10.1186/s13059-017-1211-5

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