Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma

Targeted Next-Generation Sequencing of 117 Routine Clinical Samples Provides Further Insights into the Molecular Landscape of Uveal Melanoma

Uveal melanoma (UM) has well-characterised somatic copy number alterations (SCNA) in chromosomes 1, 3, 6 and 8, in addition to mutations in <i>GNAQ, GNA11, CYSLTR2, PLCB4, BAP1, SF3B1</i> and <i>EIF1AX</i>, most being linked to metastatic-risk. To gain further insight into th...

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Bibliographic Details
Main Authors: Sophie Thornton, Sarah E. Coupland, Lisa Olohan, Julie S. Sibbring, John G. Kenny, Christiane Hertz-Fowler, Xuan Liu, Sam Haldenby, Heinrich Heimann, Rumana Hussain, Natalie Kipling, Azzam Taktak, Helen Kalirai
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
next-generation sequencing
uveal melanoma
prognostication
mutation
clinical samples
chromosome
Online Access:https://www.mdpi.com/2072-6694/12/4/1039

Internet

https://www.mdpi.com/2072-6694/12/4/1039

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