An eIF3a gene mutation dysregulates myocardium growth with left ventricular noncompaction via the p-ERK1/2 pathway

An eIF3a gene mutation dysregulates myocardium growth with left ventricular noncompaction via the p-ERK1/2 pathway

Left ventricular noncompaction (LVNC) is a heterogeneous disorder with unclear genetic causes and an unknown mechanism. eIF3a, an important member of the Eukaryotic translation initiation factor 3 (eIF3) family, is involved in multiple biological processes, including cell proliferation and migration...

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Bibliographic Details
Main Authors: Mei Ge, Xuehan Bai, Aoyi Liu, Lingjuan Liu, Jie Tian, Tiewei Lu
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Genes and Diseases
Subjects:
Differentiation
eIF3a mutation
Left ventricular non-compaction (LVNC)
Migration
p-ERK1/2
Proliferation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220300337

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http://www.sciencedirect.com/science/article/pii/S2352304220300337

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