SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.

SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer.

Hepatocellular carcinoma (HCC) is the fifth most common solid tumor in the world and the third leading cause of cancer-associated deaths. A Sleeping Beauty-mediated transposon mutagenesis screen previously identified mutations that cooperate with MYC to accelerate liver tumorigenesis. This revealed...

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Bibliographic Details
Main Authors: Shruthy Suresh, Deniz Durakoglugil, Xiaorong Zhou, Bokai Zhu, Sarah A Comerford, Chao Xing, Xian-Jin Xie, Brian York, Kathryn A O'Donnell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5362238?pdf=render

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http://europepmc.org/articles/PMC5362238?pdf=render

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