Dapagliflozin Aggravates Renal Injury via Promoting Gluconeogenesis in db/db Mice

Dapagliflozin Aggravates Renal Injury via Promoting Gluconeogenesis in db/db Mice

Background/Aims: A sodium-glucose co-transporter-2 inhibitor dapagliflozin is widely used for lowering blood glucose and its usage is limited in type 2 diabetes mellitus patients with moderate renal impairment. As its effect on kidney function is discrepant and complicated, the aim of this study is...

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Bibliographic Details
Main Authors: Yingli Jia, Jinzhao He, Liang Wang, Limin Su, Lei Lei, Wei Huang, Xiaoqiang Geng, Shun Zhang, Xiaolu Meng, Hong Zhou, Baoxue Yang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
SGLT2 inhibitor
Type 2 diabetes mellitus
Diabetic nephropathy
Glucose homeostasis
Gluconeogenic key enzymes
Online Access:https://www.karger.com/Article/FullText/487783

Internet

https://www.karger.com/Article/FullText/487783

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