An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva

An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva

We previously developed ophthalmic formulations containing tranilast nanopartaicles (ophthalmic TL-NPs formulations), and found them to show high uptake into ocular tissues. In this study, we aimed to design an in situ gel incorporating TL-NPs with 0.5–3% methylcellulose (MC, type SM-4) to ensure lo...

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Bibliographic Details
Main Authors: Noriaki Nagai, Misa Minami, Saori Deguchi, Hiroko Otake, Hiroshi Sasaki, Naoki Yamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
ophthalmic delivery
nanoparticles
in situ gelling system
tranilast
methylcellulose
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00764/full

Internet

https://www.frontiersin.org/article/10.3389/fbioe.2020.00764/full

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