Optical Methods to Study Protein-DNA Interactions in Vitro and in Living Cells at the Single-Molecule Level

Optical Methods to Study Protein-DNA Interactions in Vitro and in Living Cells at the Single-Molecule Level

The maintenance of intact genetic information, as well as the deployment of transcription for specific sets of genes, critically rely on a family of proteins interacting with DNA and recognizing specific sequences or features. The mechanisms by which these proteins search for target DNA are the subj...

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Bibliographic Details
Main Authors: Gionata Belcastro, Francesco Vanzi, Francesco S. Pavone, Carina Monico, Marco Capitanio
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:International Journal of Molecular Sciences
Subjects:
single-molecule techniques
protein-DNA interactions
facilitated diffusion
tethered particle motion
optical tweezers
magnetic tweezers
DNA curtains
single-molecule imaging
combining single-molecule fluorescence and optical trapping
in vivo transcription factors dynamics
Online Access:http://www.mdpi.com/1422-0067/14/2/3961

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http://www.mdpi.com/1422-0067/14/2/3961

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