Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

Degradation of Gadd45 mRNA by nonsense-mediated decay is essential for viability

The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular basis for this requirement is unknown. Here we show that a single, conserved NMD target, the mRNA coding for the stress response...

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Bibliographic Details
Main Authors: Jonathan O Nelson, Kristin A Moore, Alex Chapin, Julie Hollien, Mark M Metzstein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-03-01
Series:eLife
Subjects:
mRNA decay
NMD
gadd45
drosophila
upf1
upf2
Online Access:https://elifesciences.org/articles/12876

Internet

https://elifesciences.org/articles/12876

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